Snorri S Thorgeirsson Selected Research

Transforming Growth Factor alpha (TGF-alpha)

7/2005	Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas.
1/2005	Molecular mechanisms of hepatocarcinogenesis in transgenic mouse models of liver cancer.
11/2004	Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
10/2004	Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis.
6/2004	Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.
5/2004	Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
5/2003	Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
1/2003	Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.

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Snorri S Thorgeirsson Research Topics

Disease

61	Neoplasms (Cancer) 01/2022 - 01/2003
41	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 11/2002
29	Liver Neoplasms (Liver Cancer) 01/2022 - 05/2003
14	Carcinogenesis 04/2011 - 02/2003
7	Neoplasm Metastasis (Metastasis) 01/2017 - 09/2007
5	Infections 01/2021 - 11/2002
4	Cholangiocarcinoma 10/2017 - 04/2012
4	Carcinoma (Carcinomatosis) 01/2016 - 02/2004
2	Inflammation (Inflammations) 01/2016 - 05/2012
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2016 - 10/2015
2	Genomic Instability 01/2016 - 05/2004
2	Pancreatic Neoplasms (Pancreatic Cancer) 09/2013 - 11/2012
2	Hypoxia (Hypoxemia) 11/2012 - 09/2004
2	Liver Cirrhosis (Hepatic Cirrhosis) 06/2012 - 02/2004
2	Microsatellite Instability 06/2005 - 08/2002
1	Tics (Tic) 01/2022
1	Chronic Hepatitis B 01/2021
1	Obesity 10/2017
1	Adenoma (Adenomas) 01/2016
1	Wounds and Injuries (Trauma) 09/2015
1	Thyroid Neoplasms (Thyroid Cancer) 04/2015

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2004
9	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 07/2003
8	Transforming Growth Factor alpha (TGF-alpha)IBA 07/2005 - 01/2003
7	Biological ProductsIBA 10/2017 - 02/2006
6	Epithelial Cell Adhesion MoleculeIBA 01/2022 - 11/2012
6	Messenger RNA (mRNA)IBA 04/2015 - 01/2003
5	Biomarkers (Surrogate Marker)IBA 01/2019 - 11/2004
5	alpha-Fetoproteins (alpha-Fetoprotein)IBA 09/2013 - 05/2004
4	Phosphotransferases (Kinase)IBA 01/2022 - 01/2003
4	MicroRNAs (MicroRNA)IBA 01/2022 - 08/2011
4	Sorafenib (BAY 43-9006)FDA Link 01/2022 - 12/2013
4	RNA (Ribonucleic Acid)IBA 01/2021 - 10/2004
4	CateninsIBA 01/2019 - 04/2011
4	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2017 - 04/2003
4	Transcription Factors (Transcription Factor)IBA 10/2014 - 02/2003
4	beta CateninIBA 04/2007 - 05/2004
4	NF-kappa B (NF-kB)IBA 07/2005 - 01/2003
4	Complementary DNA (cDNA)IBA 11/2004 - 01/2003
4	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2004 - 01/2003
3	SulfatasesIBA 01/2017 - 04/2008
3	Transforming Growth Factor beta (TGF-beta)IBA 09/2009 - 05/2008
3	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2004 - 02/2004
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2016 - 10/2010
2	Protein Isoforms (Isoforms)IBA 01/2016 - 12/2013
2	Mitochondrial DNA (mtDNA)IBA 10/2015 - 09/2015
2	Small Interfering RNA (siRNA)IBA 09/2015 - 07/2013
2	MTOR InhibitorsIBA 04/2014 - 06/2012
2	GlypicansIBA 09/2013 - 04/2008
2	AflatoxinsIBA 08/2013 - 11/2002
2	Tyrosine Kinase InhibitorsIBA 05/2012 - 04/2012
2	CytokinesIBA 04/2012 - 05/2008
2	Proto-Oncogene Proteins c-metIBA 04/2012 - 08/2005
2	ErbB Receptors (EGF Receptor)IBA 04/2012 - 10/2007
2	pyrimidin-2-one beta-ribofuranosideIBA 09/2011 - 10/2010
2	LipidsIBA 04/2011 - 05/2003
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 10/2007 - 03/2004
2	CarcinogensIBA 09/2007 - 05/2003
2	Monomeric GTP-Binding ProteinsIBA 09/2007 - 07/2003
2	AlbuminsIBA 04/2007 - 10/2006
2	Cyclin D1IBA 04/2007 - 02/2004
2	Cadherins (E-Cadherin)IBA 04/2007 - 09/2004
2	CyclinsIBA 11/2004 - 04/2003
1	5- (2'- naphthyl)- 7- 4- chlorophenyl- (2,3,6,8- tetrahydro)pyrrolo- (3,4- e)(1,4)- diazepine- 6- thioxo- 8- (1H,7H)oneIBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	Bile Acids and Salts (Bile Acids)IBA 10/2017
1	PeriostinIBA 01/2017
1	glutamate carboxypeptidaseIBA 11/2016
1	Cisplatin (Platino)FDA LinkGeneric 02/2016
1	Histones (Histone)IBA 02/2016
1	Fluorouracil (Carac)FDA LinkGeneric 02/2016
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2016
1	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 01/2016
1	Mechanistic Target of Rapamycin Complex 2IBA 01/2016
1	Glutathione (Reduced Glutathione)IBA 01/2016
1	Metformin (Glucophage)FDA LinkGeneric 01/2016
1	MethyltransferasesIBA 01/2016
1	Galectin 3 (LGALS3)IBA 01/2016
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	Antimycin AIBA 10/2015
1	RotenoneIBA 10/2015
1	Adenosine Triphosphate (ATP)IBA 10/2015
1	ThenoyltrifluoroacetoneIBA 10/2015
1	OligomycinsIBA 10/2015
1	Nuclear Proteins (Protein, Nuclear)IBA 10/2015
1	Ethidium (Ethidium Bromide)IBA 09/2015
1	Peptides (Polypeptides)IBA 09/2015
1	CurcuminIBA 09/2015
1	teleocalcinIBA 04/2015
1	Antiviral Agents (Antivirals)IBA 11/2014
1	InterferonsIBA 11/2014
1	Tetracycline (Achromycin)FDA LinkGeneric 10/2014
1	Histone Deacetylase 2IBA 09/2014

Therapy/Procedure

15	Therapeutics 01/2022 - 02/2010
2	Transplantation 10/2014 - 09/2011
2	Lasers (Laser) 04/2012 - 10/2004
1	Drug Therapy (Chemotherapy) 02/2016
1	Hepatectomy 09/2015